I really enjoyed Middlesex. The novel follows one family across different eras and under some of the strangest circumstances. The topics of incest and hermaphroditism could have easily been used to shock the reader. And although their explorations are shocking, I am ultimately drawn in by the human and historical aspects of the narrative. I really hate to agree with Oprah on this one, but it is a great book. Minka Giertz is also pretty great. There will be more of her soon.